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smoothened

Synonyms

Adjective

1. smoothed

2. ironed

Usage
Embryonic Pathways Found to Balance the Adult Mind - Neuroscience News
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway - Nature
How the adult brain learns when to persist and when to change - EurekAlert!
After TBI, smoothened agonists cut swelling, inflammation, and neurological deficits - Medical Xpress
Activation of Smo/Gli1 pathway attenuates cardiac fibrosis by suppressing G1/S phase transition and cell proliferation in cardiac fibroblasts in mice - American Physiological Society Journal
Noncanonical Hedgehog signaling through Smoothened controls cytotoxic T cell migration in the tumor microenvironment - Science | AAAS
Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling - Frontiers
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity - Nature
Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration - Science | AAAS
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs - Nature
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain - Science | AAAS
Cyclopamine modulates smoothened receptor activity in a binding position dependent manner - Nature
Immunohistochemical expression of smoothened in periocular basal cell, squamous cell and sebaceous carcinomas - Nature
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development - Science | AAAS
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi - Nature
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling - Nature
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand - Nature
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2 - Nature
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate - Nature
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex - Nature
Structural basis of Smoothened regulation by its extracellular domains - Nature
SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling - Nature
Smoothened is a poor prognosis factor and a potential therapeutic target in glioma - Nature
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation - PNAS
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma - Science | AAAS
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling - Nature
A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury - Nature
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation - Nature
Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke - Science | AAAS
With Hebbal flyover smoothened, traffic to Bengaluru airport breathes easy - The Times of India
Regulation of the oncoprotein Smoothened by small molecules - Nature
Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium - PNAS
Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex - PNAS
Smoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling - Nature
Vertebrate Smoothened functions at the primary cilium - Nature
Structure of the human smoothened receptor bound to an antitumour agent - Nature
Hedgehog regulates smoothened activity by inducing a conformational switch - Nature
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia - Nature
G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling - Nature
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types - Nature
Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia - Nature
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine - Nature
Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice - Nature
Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila - PNAS
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis - PNAS
Patched acts catalytically to suppress the activity of Smoothened - Nature
Genetic evidence for a Smoothened-Gαi signaling axis in mammals - Science | AAAS
Purmorphamine activates the Hedgehog pathway by targeting Smoothened - Nature
Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened - Frontiers
Activating Smoothened mutations in sporadic basal-cell carcinoma - Nature
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I - Nature
Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration - Science | AAAS
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2 - Science | AAAS
Oral smoothened inhibitor for advanced basal cell carcinoma of the hand: a case report - Springer Nature Link
Endocannabinoids are conserved inhibitors of the Hedgehog pathway - PNAS
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction - Nature
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog - Nature
Patched Homolog 1 (PTCH1) Mutation in a CIC-Rearranged Sarcoma: Lack of Response to the Smoothened (SMO) Vismodegib - Cureus
Smoothened mediates medaka spermatogonia proliferation via Gli1–Rgcc–Cdk1 axis† - BioOne Complete
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype - Nature
Cholesterol and Hedgehog Signaling: Mutual Regulation and Beyond - Frontiers
Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO) - Nature
On the horizon: Hedgehog signaling to heal broken bones - Nature
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors - Nature
Fusion protein strategies for cryo-EM study of G protein-coupled receptors - Nature
Inhibiting hedgehog signal by a patched-1 antibody - Nature
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells - PNAS
Decoding the phosphorylation code in Hedgehog signal transduction - Nature
Mammalian Variations on a Theme: A Smo and Sufu Surprise - ScienceDirect.com
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector - PNAS
The energetics and ion coupling of cholesterol transport through Patched1 - Science | AAAS
Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation - PNAS
Novel therapeutic strategy against melanoma: Combined targeting of hedgehog signaling and BRD4 - Medical Xpress
Passage being smoothened for 141st Rath Yatra - The Times of India
Biography of Philip A. Beachy - PNAS
Vivo Nex review: Innovative smartphone, but needs some edges to be smoothened - The Indian Express
My wife’s potato business smoothened retirement - Daily Monitor
Major Temple Bar make-over will see cobblestones smoothened - Dublin Live
Foreign Language Equivalents
Foreign Language Equivalents of 'smoothened'
Language Equivalent   Language Equivalent
French    Spanish
Misspellings - Typos
ssmoothened,   somothened,   msoothened,   smmoothened,   smotohened,   soothened,   smoothene,   smoothenwd,   smothened,   s,oothened,   smoothneed,   smootheened,   smooothened,   smiothened,   smootehned,   smooothened,   smoohtened,   moothened,   smoothwned,   smoothenef,   smoothenrd,   smoorhened,   amoothened,   smoithened,   smoothend,   smoothemed,   smootgened,   smooyhened,   smoothenedd,   smootheneed,   smoothende,   smootthened,   smoohened,   smoothenes,   snoothened,   smopthened,   smoothned,   smpothened,   smootheend,   smoothrned,   smootheed,   dmoothened,   smoothhened,   smothened,   smootjened,   smootened,   smoothenned,   smoothebed
Words Starting with Letter - 'A'
a a battery a billion
a bit a bit much a capella singing
a cappella singing a couple of a few
a fortiori a good deal a great deal
a horizon a hundred a hundred and one
a hundred thousand a hundred times a kempis
a la carte a la mode a level
a little a lot a million
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