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secretase

Synonyms

Noun
1. enzyme

Usage

Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature

Glycemic variability associated with gamma secretase inhibitor therapy in a type 1 diabetic patient undergoing treatment for desmoid tumor: a case report - Frontiers

Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience

In A Large Clinical Trial, Gamma-Secretase Inhibitor Tarenflurbil is Found Ineffective for Mild Alzheimer Disease - Neurology Today

Phase 2 GABriella Study Represents First Step in Testing Selective Novel Y-Secretase Modulators for Prodromal Alzheimer Disease - NeurologyLive

Alzheimer’s-in-a-Dish™: Developing Drugs for Disease Prevention and Treatment - Technology Networks

Molecular mechanism of substrate recognition and cleavage by human γ-secretase - Science | AAAS

Explainable AI helps decode the substrate specificity of γ-secretase enzyme - News-Medical

Charting γ-secretase substrates by explainable AI - Nature

Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience

Therapeutic effects of a novel synthetic α-secretase - Frontiers

Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS

Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform - Nature

Secretase promotes AD progression: simultaneously cleave Notch and APP - Frontiers

Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons - Journal of Neuroscience

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease - Frontiers

Defining the minimum substrate and charge recognition model of gamma-secretase - Nature

Structural basis of human γ-secretase inhibition by anticancer clinical compounds - Nature

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature

Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease - Science Partner Journals

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease - Nature

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease - Nature

Structural basis of Notch recognition by human γ-secretase - Nature

An atomic structure of human γ-secretase - Nature

EBP1 potentiates amyloid β pathology by regulating γ-secretase - Nature

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding - Nature

γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation - Nature

Three-dimensional structure of human γ-secretase - Nature

Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature

Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition - Nature

γ-secretase directly sheds the survival receptor BCMA from plasma cells - Nature

Gamma-secretase-dependent signaling of receptor tyrosine kinases - Oncogene - Nature

Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex - Nature

Role of cholesterol in substrate recognition by $$\gamma$$ -secretase | Scientific Reports - Nature

Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors - The New England Journal of Medicine

A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss - Nature

Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate - PNAS

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation - PNAS

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio - Nature

Efficient production of a mature and functional gamma secretase protease - Nature

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production - Nature

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator - PNAS

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis - Nature

SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions - Science | AAAS

η-Secretase processing of APP inhibits neuronal activity in the hippocampus - Nature

1999: Identifying the key enzyme β-secretase - Nature

BACE1 is the major β-secretase for generation of Aβ peptides by neurons - Nature

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature

Substrate-targeting γ-secretase modulators - Nature

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms - Frontiers

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease - The New England Journal of Medicine

The beta secretase BACE1 regulates the expression of insulin receptor in the liver - Nature

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS

The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner - Nature

GSAP modulates γ-secretase specificity by inducing conformational change in PS1 - PNAS

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) - The Lancet

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase - Nature

Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks - Nature

Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells - Nature

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease - Nature

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling - Nature

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence - Nature

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma - Nature

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion | Molecular Psychiatry - Nature

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase - Nature

γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment - Journal of Neuroscience

γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential - Journal of Neuroscience

An Accomplice for γ-Secretase Brought into Focus - Science | AAAS

Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes - Nature

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease - Frontiers

Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid - Journal of Neuroscience

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease - Nature

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis | Cell Research - Nature

γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin - Journal of Neuroscience

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 - PNAS

DNA damage-inducing agents elicit γ -secretase activation mediated by oxidative stress - Nature

Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound - Journal of Neuroscience

Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients - PNAS

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology - Nature

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 - Nature

Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase - Nature

Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures - The New England Journal of Medicine

γ-Secretase: proteasome of the membrane? - Nature

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity - Nature

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells - Nature

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production - Nature

TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies - Nature

Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease - Neurology® Journals

Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein - PNAS

Structural basis of human γ-secretase assembly - PNAS

Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease - Journal of Neuroscience

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1 | Scientific Reports - Nature

Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase - Journal of Neuroscience

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease - Nature

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation - Nature

Targeting the β secretase BACE1 for Alzheimer's disease therapy - The Lancet

Foreign Language Equivalents

Foreign Language Equivalents of 'secretase'
Language	Equivalent		Language	Equivalent
French			Spanish

Misspellings - Typos

secetase,   secrretase,   secretasw,   secrrtase,   secretsse,   secretade,   secretas,   secrease,   secretae,   secretasee,   secretasse,   ssecretase,   secretasr,   swcretase,   sexretase,   secrettase,   secreetase,   seecretase,   srcretase,   secretaes,   secretsae,   secreyase,   aecretase,   secrtase,   scretase,   secretaae,   seretase,   secertase,   secreatse,   sevretase,   decretase,   secrwtase,   escretase,   secretse,   sectetase,   secrerase,   seccretase,   secretaase,   sercetase,   sceretase,   seceetase,   ecretase,   secrtease

Words Starting with Letter - 'A'

a	a battery	a billion
a bit	a bit much	a capella singing
a cappella singing	a couple of	a few
a fortiori	a good deal	a great deal
a horizon	a hundred	a hundred and one
a hundred thousand	a hundred times	a kempis
a la carte	a la mode	a level
a little	a lot	a million

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