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caspase

Synonyms

Noun
1. protease
2. peptidase, proteinase, proteolytic enzyme

Usage

Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation - Nature

Caspase-3 cleaves and activates the NADase SARM1 to promote apoptosis, linking two cell death mechanisms - PNAS

Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis - Nature

NLRP3/Caspase-1 Regulate Macrophage Efferocytosis by Modulating ADAM17-Mediated MerTK Cleavage in Liver Ischemia–Reperfusion Injury - Science Partner Journals

Dipeptidyl Peptidase 4 Mediated Caspase-8 Affects Cognitive Impairment in Mice With Alzheimer's Disease - Wiley

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection - Nature

Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock - Nature

Discovery of spectosis supports the key role of caspase-8 in determining the type of cell death in mature erythrocytes and erythrocyte death-driven immunogenicity - Nature

Caspase-8 comes in from the CYLD - Nature

cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A | Cell Death & Differentiation - Nature

Caspase 6 deficiency exacerbates inflammatory bowel disease via enterocyte necroptosis and bacterial translocation - Nature

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity - Nature

A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis - Nature

Non-genetic inactivation of caspase-3 and P53 increases cancer cell fitness by PDIA4 redistribution | Oncogene - Nature

Shooting for the stars: caspase-8–meteorin in MASH and fibrosis - Nature

Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit apoptosis - Nature

Regulation of inflammatory processes by caspases - Nature

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control - Nature

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia - Nature

Caspase-2 protects against ferroptotic cell death - Cell Death & Disease - Nature

Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks - Nature

Caspase-7 activates ASM to repair gasdermin and perforin pores - Nature

A long way to go: caspase inhibitors in clinical use - Nature

Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond - Nature

heterodimer enhances complex II assembly and elimination of pancreatic cancer cells - Nature

Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease - Nature

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7 - Science | AAAS

The prodomain of caspase-3 regulates its own removal and caspase activation - Nature

The p53-caspase-2 axis in the cell cycle and DNA damage response - Nature

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death - Nature

Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling - Nature

Caspase-1 initiates apoptosis in the absence of gasdermin D - Nature

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation - Nature

Drug-induced oxidative stress actively prevents caspase activation and hepatocyte apoptosis - Nature

Caspases and their substrates - Cell Death & Differentiation - Nature

Caspase 3 activity is required for skeletal muscle differentiation - PNAS

Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells - Science | AAAS

Apoptosis regulation by subcellular relocation of caspases - Nature

Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation - Nature

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response - Nature

Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth - Nature

Caspase involvement in autophagy - Nature

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate - Nature

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma - Nature

Caspase-11 promotes allergic airway inflammation - Nature

Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks - PNAS

Ally or traitor: the dual role of p62 in caspase-2 regulation - Cell Death & Disease - Nature

Differential roles of caspase-1 and caspase-11 in infection and inflammation - Nature

A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death | Scientific Reports - Nature

Identification of Allosteric Inhibitors against Active Caspase-6 - Nature

Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy - PNAS

TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis | Cell Death Discovery - Nature

Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies - Nature

Crystal structure of caspase-11 CARD provides insights into caspase-11 activation - Nature

Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment - Nature

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin - Nature

Evolution of caspase-mediated cell death and differentiation: twins separated at birth - Nature

Caspase-dependent non-apoptotic processes in development - Nature

Inflammatory caspase substrate specificities - ASM Journals

Caspase-2-mediated cell death is required for deleting aneuploid cells - Nature

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis - Nature

Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide - Nature

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics - Nature

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis - Nature

Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond - Frontiers

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion | Cell Death & Differentiation - Nature

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria - Nature

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia - Nature

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome - Nature

Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth - Nature

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme - PNAS

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions - Nature

Non-lethal roles of the initiator caspase Dronc in Drosophila - Frontiers

Activity of caspase-8 determines plasticity between cell death pathways - Nature

Old, new and emerging functions of caspases - Cell Death & Differentiation - Nature

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities - Nature

p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis - Nature

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition - Nature

Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage - Nature

The road to death: Caspases, cleavage, and pores - Science | AAAS

Caspase-10 is an initiator caspase in death receptor signaling - PNAS

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis - Nature

Caspase-2: the orphan caspase - Nature

Neuronal caspase-3 signaling: not only cell death - Nature

Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment - Nature

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes - Nature

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms - Journal of Neuroscience

Dronc-independent basal executioner caspase activity sustains Drosophila imaginal tissue growth - PNAS

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis - PNAS

Dimer formation drives the activation of the cell death protease caspase 9 - PNAS

Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death - Nature

Caspase activation pathways: some recent progress - Nature

A Caspase Cascade Regulating Developmental Axon Degeneration - Journal of Neuroscience

Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12 - Nature

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate - Nature

Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis - Nature

The biochemical mechanism of caspase-2 activation - Nature

Caspase-3 cleaves hnRNP K in erythroid differentiation - Nature

The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis - Nature

Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function - PNAS

Foreign Language Equivalents

Foreign Language Equivalents of 'caspase'
Language	Equivalent		Language	Equivalent
French			Spanish

Misspellings - Typos

cas[ase,   caspse,   caspsse,   caspas,   caspasse,   acspase,   casspase,   csapase,   aspase,   caspade,   caspaase,   casase,   casoase,   caspae,   caspasee,   cspase,   casapse,   xaspase,   capase,   caaspase,   caspasr,   capsase,   vaspase,   caspaes,   caapase,   casppase,   ccaspase,   caspsae,   csspase,   caspaae,   cadpase,   caspasw

Words Starting with Letter - 'A'

a	a battery	a billion
a bit	a bit much	a capella singing
a cappella singing	a couple of	a few
a fortiori	a good deal	a great deal
a horizon	a hundred	a hundred and one
a hundred thousand	a hundred times	a kempis
a la carte	a la mode	a level
a little	a lot	a million

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